Kushandiswa kweSeven Antithrombotic Agents
Kune marudzi maviri emapuroteni ane antithrombotic effect muhuturu hwenyoka, imwe inokwanisa The enzyme yakabatana ne fibrinolytic enzyme inonzi fibrinolytic enzyme (plasmine, FLE). Pamusoro pekusvibisa fibrin uye fibrinogen, Hapana kushandiswa kweplasminogen mumuviri womunhu, kwete. hydrolysis yezvimwe coagulation zvinhu Uye platelet membrane, ine pachena antithrombotic effect.Imwe yacho nekudzvanya Prothrombin gadziriro inogadziriswa kunonoka iyo coagulation maitiro, uye haina enzyme basa.
Rudzi urwu rwe enzyme rwakatanga kubudiswa neAtoda et al Uye kurukurai nzira yekudzivirira kweprotein anticoagulant, Inosimbiswa kuti mhedzisiro ye coagulation factor IX kana coagulation factor X pa calcium ion Kugadzira 1: 1 yakaoma kuti iwedzere nguva yekuvhara;Gare gare, Lu et al.kubva kuAgkistrodon acutus kumaodzanyemba kweAnhui A anticoagulant factor ACFI yakaparadzaniswa nehuturu hwenyoka.Liu Qing Liang et al.yakawana kuti ACFI ine calcium ion, Yakasimbiswawo kuti basa rayo rekudzivirira uye nzvimbo yakarongeka yakanga yakabatana ne calcium ions. Gare gare, Xu Xiaolong nevamwe vakaparadzanisa uturu hweAgkistrodon acutus kubva kuAgkistrodon acutus nenzira yakagadziridzwa yekuparadzanisa Imwe anticoagulant factor ACFI I The ongororo yekushandisa michina yakawana kuti yakafanana neAC FI uye ndeyechikamu chechipiri.Zhai Ning et al.yakazviparadzanisa ne anticoagulant factor kubva muhuturu hweAgkistrodon acutus, uye Hunhu hwayo hwepanyama nemakemikari hwakadzidzwa, uye zvakaonekwa kuti yakanga isina fibrinolytic chiitiko uye isina phospholipase A 2 chiitiko uye kubuda ropa.Qian Xiaojiang nevamwe vakaparadzanisa uturu hweAgkistrodon acutus kubva kuHunan The fibrinolytic active component yakaparadzaniswa uye yakasimbiswa nethrombolytic test in vitro Iine pachena thrombolytic effect.Lei Danqing akaparadzaniswa nenzira nhatu dzechromatography Uye basa replasmin rinovandudzwa zvakanyanya.Nokuti chikamu che plasmin chine Chikamu chekubuda ropa chakaoma kuparadzaniswa, uye kukosha kwayo kwekliniki kushandiswa hakusi pachena.Li Zhaoyan et al Kuburikidza nekuedza kuwana fibrinolytic enzyme pasina kubuda ropa Rutsigiro rwehunyanzvi rwunopihwa ne.Zhou Xianli [18] yakaratidza kuburikidza nekuyedza kuti Thrombin senge enzyme uye plasmin kubva kuAgkistrodon halys uturu zvine thrombolytic effect, asi Iyo yakananga mhedzisiro yeplasmin yakasimba kupfuura iyo yethrombin senge enzyme, Naizvozvo, thrombin senge enzyme inononoka thrombolytic agent, iyo. inoita kuti kudzoreredzwa kwemidziyo yeropa zvishoma nezvishoma, Kuwedzera kushivirira kwemidziyo yeropa munzvimbo yeischemic, uye kupona kuputika kwevascular kunokonzerwa neropa rekuyerera Cleavage ine mhedzisiro yakanaka padanho rekutanga rethrombosis, uye ese ari maviri anoshandiswa pamwechete, Inogona kuderedza. The dosage and achieve anticoagulant and thrombolytic effects.Kushandiswa kweSeven Antithrombotic Agents Kune marudzi maviri emapuroteni ane antithrombotic effect muhuturu hwenyoka, imwe inokwanisa The enzyme yakabatana nefibrinolytic enzyme inonzi fibrinolytic enzyme (plasmine, FLE). kusvibisa fibrin uye fibrinogen, Hapana activation yeplasminogen mumuviri wemunhu, hapana hydrolysis yezvimwe zvinhu coagulation Uye platelet membrane, ine pachena antithrombotic effect.Imwe yacho nekudzvanya Prothrombin gadziriro inogadziriswa kunonoka iyo coagulation maitiro, uye haina enzyme basa.
Rudzi urwu rwe enzyme rwakatanga kubudiswa neAtoda et al Uye kurukurai nzira yekudzivirira kweprotein anticoagulant, Inosimbiswa kuti mhedzisiro ye coagulation factor IX kana coagulation factor X pa calcium ion Kugadzira 1: 1 yakaoma kuti iwedzere nguva yekuvhara;Gare gare, Lu et al.kubva kuAgkistrodon acutus kumaodzanyemba kweAnhui A anticoagulant factor ACFI yakaparadzaniswa nehuturu hwenyoka.Liu Qing Liang et al.akawana kuti ACF ine calcium ion Yakasimbiswawo kuti basa rayo re anticoagulant uye chimiro chepakati chakanga chakabatana ne calcium ions.Gare gare, Xu Xiaolong nevamwe vakaparadzanisa uturu hweAgkistrodon acutus kubva kuAgkistrodon acutus nenzira yakagadziridzwa yekuparadzanisa Imwe anticoagulant factor ACFI I Chidzidzo chekushandisa michina yakawana kuti yakafanana neAC FI uye ndeyechikamu chechipiri.Zhai Ning et al.yakazviparadzanisa itsva anticoagulant factor kubva muhuturu hweAgkistrodon acutus, uye Yayo yemuviri nemakemikari ehupfumi yakaongororwa, uye yakaonekwa kuti yakanga isina fibrinolytic basa uye isina phospholipase A 2 basa uye kubuda ropa.Qian Xiaojiang nevamwe vakaparadzanisa uturu hweAgkistrodon acutus kubva kuHunan The fibrinolytic active component yakaparadzaniswa uye yakasimbiswa nethrombolytic test in vitro Iine pachena thrombolytic effect.Lei Danqing akaparadzaniswa nenzira nhatu dzechromatography Uye basa replasmin rinovandudzwa zvakanyanya.Nokuti chikamu che plasmin chine Chikamu chekubuda ropa chakaoma kuparadzaniswa, uye kukosha kwayo kwekliniki kushandiswa hakusi pachena.Li Zhaoyan et al Kuburikidza nekuedza kuwana fibrinolytic enzyme pasina kubuda ropa Rutsigiro rwehunyanzvi rwunopihwa ne.Zhou Xianli [18] yakaratidza kuburikidza nekuyedza kuti Thrombin senge enzyme uye plasmin kubva kuAgkistrodon halys uturu zvine thrombolytic effect, asi Iyo yakananga mhedzisiro yeplasmin yakasimba kupfuura iyo yethrombin senge enzyme, Naizvozvo, thrombin senge enzyme inononoka thrombolytic agent, iyo. inoita kuti kudzoreredzwa kwemidziyo yeropa zvishoma nezvishoma, Kuwedzera kushivirira kwemidziyo yeropa munzvimbo yeischemic, uye kupona kuputika kwevascular kunokonzerwa neropa rekuyerera Cleavage ine mhedzisiro yakanaka padanho rekutanga rethrombosis, uye ese ari maviri anoshandiswa pamwe chete.
Inogona kuderedza dosi uye kuwana anticoagulant uye thrombolytic mhedzisiro.
Nguva yekutumira: Oct-19-2022