[Abstract] Chinangwa: Kuona mashandiro eiyo anti-tumor chikamu I cheAgkistrodon acutus venom (AAVC-1) pane yekufambisa basa remunhu umbilical vein endothelial masero (HUVECs), uye kuongorora nzira inogona kuitika yeAAVC - Ⅰ inhibiting. angiogenesis.Nzira: HUVECs dzakagadzirwa mu vitro uye dzakabatwa neAAVC - Ⅰ (0, 20, 40, 80 μ G / ml) masero akabatwa akaiswa kwe24 h.Scratch test uye chemotactic chamber test yakashandiswa kuona maitiro eAAVC - Ⅰ pane endothelial cell migration chiitiko;RT-PCR uye Western blot yakashandiswa kuona kuchinja kwemRNA uye mapuroteni mazinga eP-selectin uye intercellular adhesion factor (ICAM-1) isati yasvika uye mushure mekurapa zvinodhaka.Zvibereko: Zvichienzaniswa neHU VECs muboka rakajairika, kugona kutama kwemasero muAAVC - Ⅰ mapoka evasungwa akadzikira kusvika pamadhigirii akasiyana, uye kutaura kweP-selectin uye ICAM-1 mRNA kwakadzikira zvakanyanya.Mhedziso: AAVC - Ⅰ inogona kutadzisa kutama kwemasero endothelial nekudzora iyo mRNA uye mapuroteni mazinga eP-selectin uye ICAM-1.
Nguva yekutumira: Nov-29-2022