[Abstract] Chinangwa Kuparadzanisa uye kuchenesa anticoagulant protein kubva kuAgkistrodon acutus venom kumaodzanyemba kweAnhui uye kuona inhibitory maitiro ayo pamunhu vascular endothelial masero.Nzira dzevanhu vascular endothelial masero EC-304 akagadzirwa mu vitro.CCK-8 colorimetry yakashandiswa kuona cytotoxicity yeanticoagulant protein chikamu cheAgkistrodon halys venom paEC-304 masero akagadzirwa mu vitro.Phase musiyano maikorosikopu yakashandiswa kuona shanduko musero morphology uye biochemistry yeEC-304 masero akabatwa neanticoagulant protein chikamu cheAgkistrodon halys venom.Mhedzisiro The anticoagulant protein fraction yeAgkistrodon halys venom yakanga iine inhibition yekukura kuri pachena paEC-304 cells (P μ The anticoagulant protein fraction yeAgkistrodon halys venom (g/mL) yakanga ine inhibitory effect paEC-304 cells, uye inhibition rate yakawedzera. nekuwedzera kwedosi;Masero eEC-304 akabatwa neanticoagulant protein kubva kuAgkistrodon halys venom airatidza kuchinja kwemorphological.Pasi pemakorosikopu, maseru aive akatenderera, nhamba yemasero akamiswa akawedzera, nhamba yezvikamu zvekukamura maseru yakaderera, uye nhamba yezvimedu zvemasero mutsika yakawedzera zvakanyanya Mhedziso The anticoagulant protein fraction yeAgkistrodon acutus venom kubva kumaodzanyemba kweAnhui Province ine inhibitory effect pamasero eEC-304, uye inducing apoptosis yeEC-304 cells inogona kuva imwe yenzira dzayo.
Nguva yekutumira: Zvita-29-2022