Institute of Snake Venom uye Snakebite, Southern Anhui Medical College
Research Institute yeWuhu Guta, Anhui Province
Tsvagiridzo yehuturu hwenyoka uye ronda renyoka reSouthern Anhui Medical College yakatanga pakati pemakore ekuma1970, uye aive nhengo yeAnhui Provincial Snake Wound Treatment Cooperation Group panguva iyoyo.Ndiyo imwe yemasangano ekutanga kuita yekutanga uye yakashandiswa tsvakiridzo pahuturu hwenyoka muChina.
Chinese name
Institute of Snake Venom uye Snakebite, Southern Anhui Medical College
nzvimbo
Anhui Province
type
chikoro
object
Muchetura Wenyoka uye Ronda reNyoka
Tsvagiridzo yakabudirira yeInstitute
Nhanganyaya kuInstitute
Tsvagiridzo yehuturu hwenyoka uye ronda renyoka reSouthern Anhui Medical College yakatanga pakati pemakore ekuma1970, uye aive nhengo yeAnhui Provincial Snake Wound Treatment Cooperation Group panguva iyoyo.Muna 1984, pasi pehutungamiriri hwaProfessor Wen Shangwu, director wedhipatimendi rekudzidzisa nekutsvaga kwevadzidzi vepakutanga vairwara, iyo Snake Poison uye Snakebite Research Office yakavambwa, inova imwe yemasangano ekutanga kuita tsvakiridzo yekutanga uye yekushandisa. pahuturu hwenyoka kuChina.Muna 2007, iyo Snake Poison uye Snakebite Research Office yakatumidzwa zita reSnake Poison Research Institute yeSouthern Anhui Medical College, uye iye zvino mutungamiriri ndiProfessor Zhang Genbao.Mumakore makumi matatu apfuura, zvakakosha uye zvakashandiswa tsvakurudzo kubudirira kwehuturu hwenyoka muchetura kumaodzanyemba kweAnhui dzakaita zvakakosha pakudzivirira nekudzora kukuvara kwenyoka uye kushandiswa kwezviwanikwa zvehuturu hwenyoka muChina;Nyoka huru dzine uturu kumaodzanyemba kweAnhui ndiAgkistrodon acutus (Agkistrodon acutus), Agkistrodon acutus, Cobra, Green Bamboo Leaf Snake, Chromium Iron Head uye Bungarus multicinctus, kunyanya Agkistrodon acutus, iyo inokanganisa zvakanyanya hutano uye hupenyu hwevanhu vemakomo.Zvidzidzo zvakaratidza kuti nyoka idzi dzine uturu dzinonyanya kuburitsa chepfu yekutenderera kweropa uye neurotoxins, izvo zvinogona kuita kuti varwere vatambure kubva pakuparadzirwa intravascular coagulation (DIC) uye kubuda ropa kwechipiri, kuvhunduka, kutadza kwenhengo dzakawanda uye zvimwe zvakakomba mhedzisiro;Kuburikidza neongororo yakarongeka pamusoro peropa toxicology yehuturu hweAgkistrodon acutus (Agkistrodon acutus) kumaodzanyemba kweAnhui, zvakaonekwa kuti DIC yakabatana nekurumwa nenyoka yaive imwe yezviratidzo zvekutanga zvechepfu, uye yakanga yakasiyana neDIC inoratidzwa mumagariro echinyakare. maonero.Naizvozvo, pfungwa ye "DIC like" syndrome muvarwere vakarumwa neAgkistrodon acutus yakatanga kutaurwa muChina (1988), Yakazivikanwa zvakare kuti thrombin senge enzyme (TLE) uye fibrinolytic enzyme (FE) iri muhuturu hweAgkistrodon acutus vaive. zvikonzero zvikuru zveiyi "DIC like" (1992).Izvi zvakakosha zvikuru kujekesa maitiro ekuchinja kweropa kune varwere vane Agkistrodon acutus, uye inopawo hwaro hwedzidziso hwekushandiswa kweiyo antivenin chaiyo kurapa dambudziko iri.Muchidzidzo chemaitiro ekubuda ropa kunokonzerwa neAgkistrodon acutus venom, zvakaonekwawo kuti uturu hwenyoka uhwu hwakakanganisa zvikamu zvitatu zvikuru zvehemostatic system (coagulation factor, platelet uye madziro etsinga yeropa), iyo iyo haemotoxin yakananga. yakakanganisa permeability ye capillaries.Panguva imwecheteyo, zvakazivikanwa kuti kubuda ropa kwakakomba kwakakonzerwa neAgkistrodon acutus venom poisoning uye kuoma kwekuzvimba kwemakumbo ekukuvadzwa kuderera kwaiva nechokuita nekuvhara kwe lymphatic supplement ye coagulation factor mu thoracic duct uye kuderera kwe lymphatic flow rate.Izvi zvakakosha uye zvakashandiswa zvakawanikwa patsvagurudzo zvakabata basa rakakosha mukushandira pamwe kwenguva refu neQimen Snakebite Research Institute mukugadzira chirongwa chekurapa kwekurumwa nenyoka ine uturu uye nekuona kuchengetedzwa kwevarwere vanorumwa nenyoka, uye vakawana zvakakosha magariro.The tsvakurudzo kubudirira zvakatevedzana akahwina Science uye Technology Achievement Award of Anhui Province, the Science and Technology Progress Award of Anhui Province (1993), uye (A) pamwero Science and Technology Achievement Collective Award Bazi Reutano (1991);Muna 1989, yakabatana neWuhan Institute of Biological Products kugadzira monoclonal antibody kurwisa thrombin senge enzyme yeAgkistrodon acutus venom, yaive budiriro yekutanga muChina;Muna 1996, yakagadzira pamwe chete uye yakagadzira zvigadzirwa zvethrombin (YWYZZ 1996 No. 118004, patent CN1141951A) neInstitute of Biological Products and Drugs of Jinan Military Region.
tsvakurudzo zvakawanikwa
Mumakore achangopfuura, marabhoritari yakaparadzanisa nekuchenesa zvakasiyana-siyana zvebioactive zvinhu kubva muhuturu husina kuchena hweAgkistrodon acutus, Agkistrodon halys neCobra kumaodzanyemba kweAnhui, senge anti hypercoagulable state enzymes, protein C activators (PCA).Ongororo dzekuyedza dzakasimbisa kuti izvi zvinoshanda zvinosanganisa zvinogona kukanganisa kugadzika kweropa, kukanganisa platelet adhesion, kuunganidzwa uye kuchengetedza basa revascular endothelial masero, uye kuve nehunyanzvi hwepamusoro uye yakaderera toxicity anticoagulation uye thrombolytic mhedzisiro, Izvi zvakakosha pakudzivirira uye kurapwa. thrombotic zvirwere uye kuvandudzwa kweropa hypercoagulability;Panguva imwecheteyo, yakawanikwa zvakare kuti PCA kubva muhuturu hwenyoka ine mhedzisiro chaiyo yekuuraya K562 leukemia masero uye inhibiting metastasis yekenza masero.Tarisiro yayo yekiriniki yekushandisa yakakura kwazvo.Hofisi yekutsvagisa yakatevedzana uye yakapedza mapurojekiti mazhinji ekutsvagisa, akadai se "Mechanism yeDIC yakakonzerwa neAgkistrodon acutus venom", "Tsvakiridzo yemaitiro ekubuda ropa kunokonzerwa neAgkistrodon acutus venom mumhuka", "Kuongororwa kwekurumwa nenyoka uye kusiyanisa kuongororwa kwayo. mhuri yenyoka nenzira yekunyora enzyme”, inotsigirwa neNational Natural Science Foundation, Ministry of Health, Dhipatimendi rehutano uye Dhipatimendi reDzidzo yeAnhui Province;Parizvino, mapurojekiti ari kuvandudzwa anosanganisira: "Tsvaga nezveHemorrhagic Anticoagulant Protein yeAgkistrodon acutus", "Ongororo yeMolecular Mechanism yeEffect yePCA kubva kuAgkistrodon halys Pallas Venom paVascular Endothelial Function", "Research Biology yeMolero. PCA kubva kuAgkistrodon acutus Venom inopesana neTumor Cells", uye Kuparadzaniswa uye Kucheneswa kweNerve Analgesic Components kubva kuCobra Venom.
Sangano rekutsvagisa uturu hwenyoka reSouth Anhui Medical College rine mamiriro akanaka ekutanga, midziyo yekutsvagisa yakakwana, chimiro chechikwata chekutsvagisa chine musoro, uye kuenderera mberi kwenzira dzekutsvagisa uye nzira dzehunyanzvi.Zvinotarisirwa kuita zvitsva mukutsvakurudza kwesayenzi, kudzidziswa kwevashandi, nezvimwewo. Zviwanikwa zvehuturu hwenyoka kumaodzanyemba kweAnhui zvakapfuma uye zvinokosha.Snake venom pharmacy mushonga une intellectual property rights kuChina.Mhedzisiro yetsvakiridzo pahwaro uye kushandiswa kwehuturu hwenyoka uye zvikamu zvadzo zvakakosha zvikuru pakuvandudzwa kwehupfumi hwehuturu hwenyoka kumaodzanyemba kweAnhui uye kukiriniki yekushandisa.
Nguva yekutumira: Nov-11-2022