[Abstract] Haemocoagulase Acutus (Halase), a new thermostatic mukukura kwe halase, yakakwira performance thrombobin senge enzyme (TLE) inotorwa kubva muhuturu hwenyoka yeAgkistrodon acutus Kudzidza pharmacokinetics yeHalase, 125Ⅰ-yakanyorwa radioisotope nzira uye neradioCAssay yakasanganiswa. precip-itate yaiiswa mumakonzo.Migumisiro yakaratidza kuti maitiro eAUC akanga akanyatsobatanidzwa nemishonga pasi penzira dzose dzakashandiswa, uye coefficients yekubatanidza yaiva 0.999 8 uye 0.999 0 maererano;zvinodhaka concen-tration muchiropa, spleen uye mwoyo yakasvika pakakwirira mushure me5 maminetsi ekutonga nepo mazhinji emamwe or-gan akasvika pairi mumaminetsi makumi matatu, ndokuzodzikira zvishoma nezvishoma;mune imwe neimwe nguva yenguva, kushandiswa kwezvinodhaka muchiropa kwaive kwakanyanya kudarika kune mamwe matukisi;Halase yakabuda zvachose uye kunyanya muweti.% Thrombin kubva kuAgkistrodon acutus imhando yethrombin yakaparadzaniswa uye yakacheneswa kubva muhuturu hweAgkistrodon acutus.Irwo rudzi rutsva rwemishonga yehemostatic yakagadzirwa neboka redu Iyo pharmacokinetics yethrombin kubva kuAgkistrodon acutus mumakonzo yakadzidzwa ne125 I-yakanyorwa radioisotope nzira uye trichloroacetic acid precipitation yakasanganiswa nekuona radioactive.Zvigumisiro zvakaratidza kuti maitiro eAUC akayerwa nenzira mbiri dzaive dzakabatana zvakanaka nedhesi, uye coefficients yekubatanidza yaiva 0.9998 uye 0.9990, maererano;Mushonga wemushonga muropa, spleen uye mwoyo wakanga uri wepamusoro-soro 5 min mushure mekutonga, nepo mune mamwe matukisi akawanda aive akakwirira 30 min mushure mekutonga, uye zvishoma nezvishoma zvishoma nezvishoma;Panguva imwe neimwe nguva, mishonga yemishonga mumucheka wechiropa yakanga yakakwirira kudarika iyo mune mamwe matukisi;Mukuwedzera, iyo thrombin excretion yeAgkistrodon acutus inopera, kunyanya neweti.
Nguva yekutumira: Zvita-08-2022