Uturu Hwenyoka Hunobva kuAgkistrodon (Nyoka nhanho shanu) Hunofanira Kurapwa NeAntihematic Serum

Tsanangudzo Pfupi

Miedzo miviri yemakiriniki yakaitwa, muedzo we-randomized placebo-controlled controlled controlled controlled randomized.Maronda ese aibuda ropa nekuchekwa kwemadziro edumbu pakuvhiya mudumbu.Iwo makuru ekurapa indexes aive kurasikirwa kweropa, hemostasis nguva uye kurasikirwa kweropa pane imwe unit nzvimbo.Randomized placebo mumakiriniki ekuedzwa mune 180 zviitiko zvevanhu: chikamu chezvakaenzana zvakaenzana mapoinzi kune placebo, 2 u uye 3 u mapoka matatu, iyo preoperative 15-20 maminetsi imwe chete intravenous dosing, mhedzisiro inoratidza iyi miviri miviri mukubuda ropa, kubuda ropa nguva uye kurasikirwa kweropa pane imwe unit area index kwaive kwakakwirira kune placebo, asi hapana hukama hwekugadzirisa-mhinduro pakati pemapoka maviri.Muchiedzo chakanaka chekutonga, paiva nevarwere ve324 muboka rekuedza uye varwere ve108 vari muboka rekutonga, uye imwe yero ye2U yakapiwa muboka rekuedza 15-20 maminetsi vasati vavhiyiwa nejekiseni rimwe chete remutsinga.Hapana kuita kwakashata kwakaonekwa mune bvunzo dziri pamusoro.

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Zvidzidzo zvakaratidza kuti nyoka dzine huturu idzi dzinonyanya kuburitsa chepfu inotenderera muropa uye neurotoxins, izvo zvinogona kukonzera diffuse intravascular coagulation (DIC) uye kubuda ropa kunotevera, kuvhunduka uye kutadza kwenhengo dzakawanda.Zvichienderana nekuongorora kwakarongeka kweropa toxicology yehuturu hwenyoka kumaodzanyemba kweAnhui, DIC yakawanikwa iri imwe yemaitiro ekuzvarwa kwevarwere vakakuvadzwa nenyoka vane chepfu yekutanga, izvo zvaive zvakasiyana nekutaura kwechinyakare kweDIC.Naizvozvo, pfungwa ye "DIC senge" chirwere muvarwere vanorumwa nenyoka yakakurudzirwa kekutanga muChina (1988).Zvakaonekwa kuti TLE neFE ndizvo zvakakonzeresa iyi "DIC like" (1992).Izvi zvakakosha zvikuru kujekesa maitiro ekuchinja kweropa kune varwere vane nhanho-nhanho yehuturu hwenyoka, uye inopawo hwaro hwekufungidzira hwekushandiswa kweantivenom chaiyo kurapa dambudziko iri.

Mukutsvagisa nzira yekubuda ropa kunokonzerwa nenhanho shanu dzehuturu hwenyoka, zvakaonekwa zvakare kuti uturu hwenyoka uhwu hune mhedzisiro pazvikamu zvitatu zvehemostatic system yemuviri (coagulation factor, maplatelet uye tsinga yeropa), pakati pekubuda ropa. chepfu inokanganisa zvakananga kupera kwema capillaries.Panguva imwecheteyo, zvakaonekwa kuti kubuda ropa kwakanyanya uye kuputika kwemakumbo akakuvadzwa kwakanga kusiri nyore kugadzirisa, izvo zvaive zvakabatana nekuvharwa kweropa re thoracic duct lymphatic coagulation factor uye kushaya simba kwe lymphatic flow.Mukubatana kwenguva refu neQimen Snakebite Institute, izvi zvakakosha uye zvakashandiswa mhedzisiro yekutsvagisa zvakabata basa rakakosha mukugadzira chirongwa chekurapa kwekurumwa nenyoka uye kuve nechokwadi chekuchengetedzwa kwevarwere vanorumwa nenyoka, uye vakawana zvakakosha zvemagariro.The tsvakurudzo kubudirira akahwina Science uye Technology Achievement Award of Anhui Province, Science and Technology Progress Award of Anhui Province (1993), Bazi Reutano (A) Giredhi Sayenzi uye zvemichina Achievement Group Award (1991);Muna 1989, kambani yakabatana neWuhan Institute of Biological Products kugadzira monoclonal antibody kurwisa penta nyoka uturu thrombin, yaive yekutanga kubudirira muChina.Muna 1996, kambani yakagadzira pamwe nekugadzira zvigadzirwa zvethrombin neInstitute of Biological Products uye Drugs yeJinan Military Command (Yuwei Drug Approval No. 118004, Patent CN1141951A).