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Zvinomwe Antithrombotic Effects Yakashandiswa

Tsanangudzo Pfupi

Kune marudzi maviri emapuroteni muhuturu hwenyoka, imwe yacho yakati twasa.Enzayimu inonyungudutsa fibrin (protolysin) inonzi fibrin (protolysin) enzyme (Ipfupi yeplasminase,fi b ri no L yt I cenz YM E, FLE).Pamusoro pekusvibisa fibrin uye fibrinogen, Hapana activation yeplasminogen mumuviri wemunhu, hapana hydrolysis yezvimwe zvinhu coagulation Uye platelet membrane, ine pachena antithrombotic effect.Imwe yacho kuburikidza nekudzvanyiriraProthrombin inomisikidzwa kuti inonoke iyo coagulation maitiro uye haina enzyme basa.

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Iyi enzyme yakatanga kugadzirwa neATODA nezvimwewo kubva kuJapan yellow-green iron musoro wenyoka uturu
Iyo anticoagulant maitiro eiyo anticoagulant protein yakakurukurwa.
Izvi zvinoratidzwa nekudyidzana ne clotting factor IX kana clotting factor X mu calcium ions
Kuumbwa kwe1: 1 yakaoma kuti uwane kuwedzera nguva ye coagulation;Gare gare,
LU et al.Agk I strodona CU
ACFI, anticoagulant factor, yakaparadzaniswa nehuturu hwenyoka.Liu Qing
Liang et al.akadzidza anticoagulant factor uye akaona kuti AC FI yaive necalcium ion
Uye basa rayo reanticoagulant uye chimiro chepakati chaive chakabatana ne calcium ions.
Zvadaro, Xu Xiaolong et al.akaparadzanisa uturu hweagkistrodon halys nekuvandudza nzira yekuparadzanisa
Imwe anticoagulant factor, ACFI I, uye anticoagulant yeiyi anticoagulant factor.
Iyo yekumisikidza nzira yekutsvaga, yakaona kuti yakafanana neAC FI, ndiyo yechipiri mhando.zhai
Ning et al.yakabvisa chinhu chitsva cheanticoagulant kubva muhuturu hweagkistrodon agkistrodon
Zvakaonekwa kuti pakanga pasina fibrinolytic basa uye phospholipase A
Kuita uye kubuda ropa basa.Qian Xiaojiang et al kubva kuHunan vakagadzira agkistrodon venom points
Fibrinolytic inoshanda zvikamu zvakaparadzaniswa uye zvakasimbiswa ne thrombolytic assay in vitro
Iine pachena thrombolytic effect.Kuchena kwakaparadzaniswa nenzira nhatu dzechromatographic
Uye basa re enzyme rakavandudzwa zvakanyanya.Nekuti chikamu che plasminase chine
Chikamu chekubuda ropa chakaoma kupatsanurwa uye kukosha kwayo kwekiriniki yekushandisa haisi pachena.Li Zhaoyan nevamwe.
Kuburikidza nekuedza kuwana fibrinolytic enzyme pasina kubuda ropa, fibrinolytic enzyme kliniki mhinduro
Nekutsigirwa kwehunyanzvi.Zhou Xianli [18] akaratidza kuburikidza nemiedzo kuti
Ose ari maviri thrombin uye fibrinolytic enzyme yeagkistrodon halys venom zvine thrombolytic effect, asi.
Mhedzisiro yakananga yefibrinolytic enzyme yakasimba kupfuura thrombin.
Saka thrombin inononoka thrombolytic, inofambira mberi recanalization yemidziyo yeropa,
Wedzera kushivirira kwemidziyo yeropa munzvimbo ye ischemic, dzivisa kusvibiswa kweropa kunokonzerwa nekuputika kwevascular.
Cleft, ine mhedzisiro iri nani padanho rekutanga rethrombosis, iyo miviri yakasanganiswa kushandiswa